Two people were killed and three others injured early Tuesday morning in a wrong-way crash, possibly involving a DUI driver, in downtown Los Angeles, authorities said.

The crash happened at about 2 a.m. on the northbound 110 Freeway near 9th Street, the California Highway Patrol said. Several traffic lanes were closed.

The driver of a Lexus SUV was driving southbound in the northbound lanes when it collided with a Toyota Corolla with two people inside, according to CHP Sgt. Jeff Lane.

Both of the people in the Toyota Corolla died at the scene. Their identities have not been released.

The man driving the SUV was briefly trapped in the vehicle and taken to a hospital with serious injuries. A woman passenger in the SUV and a child in the backseat sustained minor injuries, Lane said.

A third vehicle hit the Toyota after the initial crash, Lane said.

The No. 3, 4, and 5 lanes of the northbound 110 Freeway at 9th Street, and the 10 Freeway to the 110 Freeway transition road from both directions were closed for the investigation.