Three people were killed in a fiery multi-vehicle collision in Burbank, and police Wednesday morning were investigating whether it was a hit-and-run.

Police and firefighters responded at 11:50 p.m. Tuesday to North Glenoaks Boulevard and Andover Drive, near the Burbank Tennis Center, where two people had been ejected from one vehicle and one person was trapped in a vehicle that was on fire, said a Burbank Police Department spokesman.

The three victims were pronounced dead at the scene, the spokesman said. Two others were injured and taken to the hospital.

“We’re very early in the investigation,” the spokesman said. “There were at least two cars involved. We’re not entirely sure if it was a hit-and-run. Our traffic investigators will be investigating for several hours.”

Several parked vehicles were struck during the collision, police said.

Glenoaks Boulevard was expected to be closed for several hours due to the collision, the spokesman said.