Los Angeles County reported its fourth case of the Omicron variant of COVID-19 Wednesday, saying the case is possibly the result of local transmission, unlike the previous infections that are believed to been travel-related.

According to the county Department of Public Health, the latest patient is fully vaccinated — including a booster shot. The unidentified person had “mild symptoms” and had close contact with “multiple” people who have since tested positive for COVID-19, although it is still unknown if those cases involve the Omicron variant, which is blamed for a spike in infections in South Africa, where it was first detected.

Some of the patient’s close contacts were also fully vaccinated, but the status of some others is still undetermined, health officials said.

The heavily mutated coronavirus variant known as omicron has arrived in LA county. Hetty Chang reports for the NBC4 News at 11 p.m. on Dec. 2, 2021. 

The county did not provide other details of the new Omicron patient, only calling the case “a possible result of local transmission,” meaning the variant is now being spread within the community.

“The identification of a case of Omicron attributed to community spread is a reminder that we all need to take necessary precautions to prevent transmission of COVID-19,” county Public Health Director Barbara Ferrer said in a statement. “Celebrating with those we love this holiday season requires layering on the protections that are now available to us: vaccinations, boosters, masking up, and testing. This is how we slow the spread of Delta and Omicron.”

Los Angeles County reported its first Omicron case last week, involving a person who had traveled to South Africa via London. The second and third cases were confirmed Monday — one involving a USC student who had traveled to the East Coast for the Thanksgiving holiday, and another involving a person who had recently traveled to West Africa.

All three infections were deemed by health officials to be “travel- related,” and all three patients were fully vaccinated and experienced only mild symptoms, county officials said.

The city of Long Beach, which has a health department separate from the county, confirmed its first Omicron case Tuesday. That person was also fully vaccinated, did not develop any symptoms and had recently traveled internationally, but not to the southern Africa region.

What is Omicron?

Omicron is a new variant of COVID-19, which the World Health Organization designated a “variant of concern” on Nov. 26, 2021. The name comes from the letter in the Greek alphabet.

The omicron variant was first detected by scientists in South Africa, where it is believed to be the cause of a recent spike in cases in the Gauteng province.

It’s unclear where the variant first emerged. After South Africa alerted the WHO to the presence of omicron, the Netherlands stated they saw omicron cases up to a week earlier. The variant has since been seen in travelers arriving in several countries, from Australia to Israel to the Netherlands, since South Africa alerted the WHO.

Because the variant was announced so recently, there is still much we don’t know about how it differs from other forms of COVID-19. Scientists worldwide are studying the omicron variant to gather more information.

The variant appears to have a high number of mutations, or genetic changes, on its spike protein, a protein found on the surface of the virus that plays a role in how easily the virus spreads between people.

Lawrence Young, a virologist at the University of Warwick, described omicron as “the most heavily mutated version of the virus we have seen.”

Is Omicron More Transmissible?

It’s not yet known for sure if the omicron variant of COVID-19 is more transmissible. There’s not yet much data, and the data that exists hasn’t been studied thoroughly at this point in time.

However, scientists are concerned that the large number — more than 30 — and kind of genetic changes to the spike protein, make omicron more transmissible.

Scientists are closely watching how the new variant might affect people who caught COVID-19 and recovered.

A group of experts the organization gathered to discuss available data led the WHO to say that “preliminary evidence suggests an increased risk of reinfection with this variant,” as compared to other variants.

That means people who have immunity to COVID-19 could catch it again, with the omicron variant.

Sharon Peacock, who has led genetic sequencing of COVID-19 in Britain at the University of Cambridge, says that while the mutations in omicron match the kinds that would increase transmissibility, “the significance of many of the mutations is still not known.”

Is Omicron More Concerning Than the Delta Variant?

Delta is still, by far, the most dominant form of COVID-19 worldwide.

There is much that is unknown about omicron, including whether it is more contagious than previous versions, makes people sicker, thwarts the vaccine or more easily breaks through the immunity that people get from a bout of COVID-19. World health authorities have yet to link any deaths to omicron.

For now, the extra-contagious delta variant accounts for practically all cases in the U.S. and continues to inflict misery at a time when many hospitals are struggling with nurse shortages and a backlog of patients undergoing procedures that had been put off early in the pandemic.

The fear is that omicron will foist even more patients, and perhaps sicker ones, onto hospitals.

Does Omicron Cause More Severe Disease?

Like the data about transmissibility, we don’t yet know for sure whether omicron causes more severe illness than other forms of COVID-19, or whether there is an increased risk of death.

There is not yet any indication omicron causes more severe disease.

Early reports from scientists in South Africa, who are already dealing with a rapid increase in cases, suggest that omicron cases tend to have mild symptoms.

“We’ve seen a sharp increase in cases for the past 10 days. So far they have mostly been very mild cases, with patients having flu-like symptoms: dry coughs, fever, night sweats, a lot of body pains,” said Dr. Unben Pillay, a general practitioner in South Africa’s Gauteng province where 81% of the new cases have been reported.

Most of those cases were mild enough to be treated at home, rather than in hospitals. However, Pillay noted that, with COVID-19, hospitalizations tend to occur several days after cases start to rise.

The omicron variant of COVID-19 isn’t in the U.S. yet, but health officials urge Americans to get vaccinated and get their booster shot as soon as possible. Toni Guinyard reports for Today in LA on Tuesday, Nov. 30, 2021.

Most of the omicron cases in South Africa so far have been in relatively young people, in their 20s and 30s, Pillay noted. Older people may see more severe symptoms if infected.

And, as has been the case with other forms of COVID-19, vaccinated people appear to fare better than unvaccinated people when it comes to omicron.

How Can I Protect Myself Against Omicron?

The same tools used to stop previous versions of COVID-19 will help when it comes to omicron.

Masks in indoor settings, where ventilation tends to be worse and the virus tends to spread more easily if it’s present, can help protect you from becoming infected, or protect others if you’re sick and haven’t yet realized it.

And vaccines are still important. Scientists are studying whether current vaccines are less effective against omicron, which we don’t have enough data to say for certain is the case.

Even if we end up needing an omicron-specific COVID-19 vaccine, partial protection from the vaccines we have now is better than no protection at all.

“There’s lots of reasons for optimism that this is not some horrible situation that we’re in. The vaccines should hold up against severe disease, especially with people who are boosted,” Dr. Eric Topol, founder and director of the Scripps Research Translational Institute, told CNBC on Tuesday.

Boosters can also play an important role, reintroducing your body to what the virus is like, causing your immune system to produce higher levels of antibodies against COVID-19.

All vaccines also boost T cells, another part of the immune system’s response to disease, and one that is less affected by the differences between variants of COVID.

“Our T cells are very insensitive, not affected by variants, to any significant degree,” Topol said.

In the end, gathering solid data to make certain statements about the effects of omicron will take time.

“Careful studies take time,” Dr. Ashish Jha, Dean of Brown University’s School of Public Health, said on the TODAY show. “You have to grow the virus, run the tests, see what’s happening in people. There is no way to go any faster than that.”

In the meantime, President Joe Biden said, “this variant is a cause for concern, not a cause for panic.”